Maternal and fetal microchimerism in granulocytes

Fetal cell microchimerism in the maternal heart: baby gives back.

In this issue of Circulation Research, Kara et al1 present an elegant series of experiments demonstrating that after murine maternal myocardial infarction, fetal cells engraft and differentiate into endothelial cells, smooth muscle cells, and cardiomyocytes at the site of injury. These cells, when isolated and cocultured with neonatal cells, appear to be capable of differentiating into beating ...

Pretransplantation fetal-maternal microchimerism in pediatric liver transplantation from mother

AIM To investigate the rates of pretransplantation fetal-maternal microchimerism (MC) and its effect on rejection in children receiving maternal liver grafts. METHODS DNA or blood samples before liver transplantation (LT) were available in 45 pediatric patients and their mothers. The presence of pretransplantation MC to non-inherited maternal antigens (NIMAs) (NIMA-MC) in the peripheral blood...

Fetal microchimerism and cancer.

The persistence of fetal stem cells with multilineage potential in women who have been pregnant, a phenomenon known as fetal microchimerism, is emerging as a potential contributing factor in certain diseases, including cancer. For example, fetal microchimerism has been implicated in autoimmune disease, wound healing, and cancer. Studies of this phenomenon may provide a novel perspective on canc...

[Fetal microchimerism and autoimmune disease].

Microchimerism is defined by the presence of circulating cells, bi-directionally transferred from one genetically distinct individual to another. The acquisition and persistence of fetal cell microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Some of the autoimmune diseases that show a predilection...

Maternal Microchimerism Histocompatibility and MHC Zygosity on Influence of Maternal-Fetal